Increased PHGDH expression promotes aberrant melanin accumulation
Abstract Background Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas. Methods In order to study the effect of increased PHGDH expression in tissues in vivo, w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-07-01
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| Series: | BMC Cancer |
| Online Access: | http://link.springer.com/article/10.1186/s12885-019-5933-5 |