Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis

Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis

Anti-angiogenic treatments against αvβ3-integrin fail to block tumour growth in the long term, which suggests that the tumour vasculature escapes from angiogenesis inhibition through αvβ3-integrin-independent mechanisms. Here, we show that suppression of β3-integrin in mice leads to the activation o...

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Bibliographic Details
Main Authors: Tim S. Ellison, Samuel J. Atkinson, Veronica Steri, Benjamin M. Kirkup, Michael E. J. Preedy, Robert T. Johnson, Christiana Ruhrberg, Dylan R. Edwards, Jochen G. Schneider, Katherine Weilbaecher, Stephen D. Robinson
Format: Article
Language:English
Published: The Company of Biologists 2015-09-01
Series:Disease Models & Mechanisms
Subjects:
Integrin
Neuropilin-1
Angiogenesis
Tumour
Focal adhesion
Online Access:http://dmm.biologists.org/content/8/9/1105

Internet

http://dmm.biologists.org/content/8/9/1105

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