Integrating genome-wide association study with regulatory SNP annotations identified novel candidate genes for osteoporosis

Integrating genome-wide association study with regulatory SNP annotations identified novel candidate genes for osteoporosis

Aims: Osteoporosis (OP) is a metabolic bone disease, characterized by a decrease in bone mineral density (BMD). However, the research of regulatory variants has been limited for BMD. In this study, we aimed to explore novel regulatory genetic variants associated with BMD. Methods: We conducted an in...

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Bibliographic Details
Main Authors: Yumeng Jia, Xin Qi, Mei Ma, Shiqiang Cheng, Bolun Cheng, Chujun Liang, Xiong Guo, Feng Zhang
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2023-02-01
Series:Bone & Joint Research
Subjects:
osteoporosis
bone mineral density
regulatory single nucleotide polymorphism
genome-wide association studies
bone mineral density (bmd)
single nucleotide polymorphisms
cartilage
chondrocyte
metabolic bone disease
mesenchymal stem cell (msc)
hip
osteoblasts
rnas
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.122.BJR-2022-0206.R1

Internet

https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.122.BJR-2022-0206.R1

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