TMED2 binding restricts SMO to the ER and Golgi compartments.

TMED2 binding restricts SMO to the ER and Golgi compartments.

Hedgehog (HH) signaling is important for embryonic pattering and stem cell differentiation. The G protein-coupled receptor (GPCR) Smoothened (SMO) is the key HH signal transducer modulating both transcription-dependent and transcription-independent responses. We show that SMO protects naive mouse em...

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Bibliographic Details
Main Authors: Giulio Di Minin, Markus Holzner, Alice Grison, Charles E Dumeau, Wesley Chan, Asun Monfort, Loydie A Jerome-Majewska, Henk Roelink, Anton Wutz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-03-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001596

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https://doi.org/10.1371/journal.pbio.3001596

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