Screening an In-House Isoquinoline Alkaloids Library for New Blockers of Voltage-Gated Na<sup>+</sup> Channels Using Voltage Sensor Fluorescent Probes: Hits and Biases

Screening an In-House Isoquinoline Alkaloids Library for New Blockers of Voltage-Gated Na<sup>+</sup> Channels Using Voltage Sensor Fluorescent Probes: Hits and Biases

Voltage-gated Na<sup>+</sup> (Na<sub>V</sub>) channels are significant therapeutic targets for the treatment of cardiac and neurological disorders, thus promoting the search for novel Na<sub>V</sub> channel ligands. With the objective of discovering new blockers o...

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Bibliographic Details
Main Authors: Quentin Coquerel, Claire Legendre, Jacinthe Frangieh, Stephan De Waard, Jérôme Montnach, Leos Cmarko, Joseph Khoury, Charifat Said Hassane, Dimitri Bréard, Benjamin Siegler, Ziad Fajloun, Harold De Pomyers, Kamel Mabrouk, Norbert Weiss, Daniel Henrion, Pascal Richomme, César Mattei, Michel De Waard, Anne-Marie Le Ray, Christian Legros
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
voltage-gated sodium channel
isoquinoline alkaloids
oxoaporphine
voltage sensor probes
Na<sup>+</sup> fluorescent probe ANG-2
GH3b6 cells
Online Access:https://www.mdpi.com/1420-3049/27/13/4133

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https://www.mdpi.com/1420-3049/27/13/4133

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