Activation of STING by cGAMP Regulates MDSCs to Suppress Tumor Metastasis via Reversing Epithelial-Mesenchymal Transition

Activation of STING by cGAMP Regulates MDSCs to Suppress Tumor Metastasis via Reversing Epithelial-Mesenchymal Transition

The role of cGAMP stimulating cGAS-cGAMP-STING-IRF3 pathway to inhibit tumor growth was well-established. Herein, the efficiency and pharmacological mechanism of cGAMP on regulating tumor metastasis was investigated. The effects of cGAMP regulating CD8+ T cells and myeloid-derived suppressor cells (...

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Bibliographic Details
Main Authors: Hao Cheng, Qiming Xu, Xing Lu, Hong Yuan, Tiejun Li, Yuefan Zhang, Xiangshi Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Oncology
Subjects:
cGAMP
myeloid-derived suppressor cells
metastasis
epithelial-mesenchymal transition
STING
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00896/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00896/full

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