Replacing Lu-177 with Tb-161 in DOTA-TATE and PSMA-617 therapy: potential dosimetric implications for activity selection

Replacing Lu-177 with Tb-161 in DOTA-TATE and PSMA-617 therapy: potential dosimetric implications for activity selection

Abstract Aim To explore the dosimetric effect of substituting Lu-177 with Tb-161 in targeted radionuclide therapy (TRT) using the registered tracers DOTA-TATE and PSMA-617. Methods Using established kinetic data for [177Lu]Lu-DOTA-TATE and [177Lu]Lu-PSMA-617, radiation absorbed doses to typical tumo...

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Bibliographic Details
Main Authors: Frederik A. Verburg, Erik de Blois, Stijn Koolen, Mark W. Konijnenberg
Format: Article
Language:English
Published: SpringerOpen 2023-11-01
Series:EJNMMI Physics
Subjects:
[177Lu]Lu-DOTA-TATE
[177Lu]Lu-PSMA-617
Radionuclide therapy
Dosimetry
Terbium-161
Online Access:https://doi.org/10.1186/s40658-023-00589-w

Internet

https://doi.org/10.1186/s40658-023-00589-w

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