A combination of metformin and epigallocatechin gallate potentiates glioma chemotherapy in vivo

A combination of metformin and epigallocatechin gallate potentiates glioma chemotherapy in vivo

Glioma is the most devastating high-grade tumor of the central nervous system, with dismal prognosis. Existing treatment modality does not provide substantial benefit to patients and demands novel strategies. One of the first-line treatments for glioma, temozolomide, provides marginal benefit to gli...

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Bibliographic Details
Main Authors: Shreyas S. Kuduvalli, Precilla S. Daisy, Anandraj Vaithy, Mugilarasi Purushothaman, Arumugam Ramachandran Muralidharan, Kumar B. Agiesh, Markus Mezger, Justin S. Antony, Madhu Subramani, Biswajit Dubashi, Indrani Biswas, K. P. Guruprasad, T. S. Anitha
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
glioma
metformin
epigallocatechin gallate (EGCG)
molecular docking
quantum mechanics (QM)
ROS-reactive oxygen species
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1096614/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1096614/full

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