Activation of the insulin receptor by an insulin mimetic peptide

Activation of the insulin receptor by an insulin mimetic peptide

Genetic mutations of insulin receptor (IR) cause severe insulin resistance syndromes with no current treatment or cure. Here, the authors present that insulin-independent IR activation mechanism by peptide agonist which activate non-functional IR mutants that cause the insulin resistance syndromes.

Bibliographic Details
Main Authors: Junhee Park, Jie Li, John P. Mayer, Kerri A. Ball, Jiayi Wu, Catherine Hall, Domenico Accili, Michael H. B. Stowell, Xiao-chen Bai, Eunhee Choi
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33274-0

Internet

https://doi.org/10.1038/s41467-022-33274-0

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