Activation of the insulin receptor by an insulin mimetic peptide
Genetic mutations of insulin receptor (IR) cause severe insulin resistance syndromes with no current treatment or cure. Here, the authors present that insulin-independent IR activation mechanism by peptide agonist which activate non-functional IR mutants that cause the insulin resistance syndromes.
Main Authors: | Junhee Park, Jie Li, John P. Mayer, Kerri A. Ball, Jiayi Wu, Catherine Hall, Domenico Accili, Michael H. B. Stowell, Xiao-chen Bai, Eunhee Choi |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-09-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-33274-0 |
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