Impact of tumor suppressor genes inactivation on the multidrug resistance phenotype of hepatocellular carcinoma cells

Impact of tumor suppressor genes inactivation on the multidrug resistance phenotype of hepatocellular carcinoma cells

The response of advanced hepatocellular carcinoma (HCC) to pharmacological treatments is unsatisfactory and heterogeneous. Inactivation of tumor suppressor genes (TSGs) by genetic and epigenetic events is frequent in HCC. This study aimed at investigating the impact of frequently altered TSGs on HCC...

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Bibliographic Details
Main Authors: Anabel Sanchez-Martin, Paula Sanchon-Sanchez, Marta R. Romero, Jose J.G. Marin, Oscar Briz
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Chemoresistance
Collateral sensitivity
CRISPR/Cas9
Mutation
p53
Tumor heterogeneity
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223010004

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http://www.sciencedirect.com/science/article/pii/S0753332223010004

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