JNK1/2 represses Lkb 1-deficiency-induced lung squamous cell carcinoma progression

JNK1/2 represses Lkb 1-deficiency-induced lung squamous cell carcinoma progression

LKB1 is frequently mutated in lung squamous cell carcinomas. Here, the authors show that sole LKB1 depletion is sufficient to drive the development of this cancer, where downstream defective MKK7-JNK1/2 signalling activates the ∆Np63/p63 pathway to induce subsequent epithelial cells transformation a...

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Bibliographic Details
Main Authors: Jian Liu, Tianyuan Wang, Chad J. Creighton, San-Pin Wu, Madhumita Ray, Kyathanahalli S. Janardhan, Cynthia J. Willson, Sung-Nam Cho, Patricia D. Castro, Michael M. Ittmann, Jian-Liang Li, Roger J. Davis, Francesco J. DeMayo
Format: Article
Language:English
Published: Nature Portfolio 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09843-1

Internet

https://doi.org/10.1038/s41467-019-09843-1

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