Long-Term Hepatitis B Virus Infection Induces Cytopathic Effects in Primary Human Hepatocytes, and Can Be Partially Reversed by Antiviral Therapy

Long-Term Hepatitis B Virus Infection Induces Cytopathic Effects in Primary Human Hepatocytes, and Can Be Partially Reversed by Antiviral Therapy

ABSTRACT Chronic infection of hepatitis B virus (HBV) remains a major health burden worldwide. While the immune response has been recognized to play crucial roles in HBV pathogenesis, the direct cytopathic effects of HBV infection and replication on host hepatocytes and the HBV-host interactions are...

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Bibliographic Details
Main Authors: Wenjing Zai, Kongying Hu, Jianyu Ye, Jiahui Ding, Chao Huang, Yaming Li, Zhong Fang, Min Wu, Cong Wang, Jieliang Chen, Zhenghong Yuan
Format: Article
Language:English
Published: American Society for Microbiology 2022-02-01
Series:Microbiology Spectrum
Subjects:
long-term HBV infection
quantitative temporal proteomics
cytopathic effects
nucleot(s)ide analogues
viral-host interaction
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01328-21

Internet

https://journals.asm.org/doi/10.1128/spectrum.01328-21

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