Identification of Triazolopyrimidinyl Scaffold SARS-CoV-2 Papain-Like Protease (PL<sup>pro</sup>) Inhibitor

Identification of Triazolopyrimidinyl Scaffold SARS-CoV-2 Papain-Like Protease (PL<sup>pro</sup>) Inhibitor

The global impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its companion disease, COVID-19, has reminded us of the importance of basic coronaviral research. In this study, a comprehensive approach using molecular docking, in vitro assays, and molecular dynamics simulations...

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Bibliographic Details
Main Authors: Sebastjan Kralj, Marko Jukič, Miha Bahun, Luka Kranjc, Anja Kolarič, Milan Hodošček, Nataša Poklar Ulrih, Urban Bren
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Pharmaceutics
Subjects:
drug design
protease inhibitor
SARS-CoV-2
papain-like protease
PL<sup>pro</sup>
antiviral design
Online Access:https://www.mdpi.com/1999-4923/16/2/169

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https://www.mdpi.com/1999-4923/16/2/169

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