Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women

Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women

Abstract Background Breast cancer is a leading cause of death in premenopausal women. Progesterone drives expansion of luminal progenitor cells, leading to the development of poor-prognostic breast cancers. However, it is not known if antagonising progesterone can prevent breast cancers in humans. W...

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Bibliographic Details
Main Authors: Thomas E. Bartlett, Iona Evans, Allison Jones, James E. Barrett, Shaun Haran, Daniel Reisel, Kiriaki Papaikonomou, Louise Jones, Chiara Herzog, Nora Pashayan, Bruno M. Simões, Robert B. Clarke, D. Gareth Evans, Talayeh S. Ghezelayagh, Sakthivignesh Ponandai-Srinivasan, Nageswara R. Boggavarapu, Parameswaran G. Lalitkumar, Sacha J. Howell, Rosa Ana Risques, Angelique Flöter Rådestad, Louis Dubeau, Kristina Gemzell-Danielsson, Martin Widschwendter
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Genome Medicine
Subjects:
Breast cancer
Prevention
Antiprogestins
BRCA1
Intermediate surrogate marker
Epigenetics
Online Access:https://doi.org/10.1186/s13073-022-01063-5

Internet

https://doi.org/10.1186/s13073-022-01063-5

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