Viral Particle-Mediated SAMHD1 Depletion Sensitizes Refractory Glioblastoma to DNA-Damaging Therapeutics by Impairing Homologous Recombination

Viral Particle-Mediated SAMHD1 Depletion Sensitizes Refractory Glioblastoma to DNA-Damaging Therapeutics by Impairing Homologous Recombination

The current standard-of-care treatment for glioblastoma includes DNA damaging agents, γ-irradiation (IR) and temozolomide (TMZ). These treatments fail frequently and there is limited alternative strategy. Therefore, identifying a new therapeutic target is urgently needed to develop a strategy that i...

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Bibliographic Details
Main Authors: Waaqo Daddacha, Dominique Monroe, Kristen Carver, Edidiong R. Usoro, Ahmet Alptekin, Hongyan Xu, Satoru Osuka, Ali S. Arbab, Daitoku Sakamuro
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cancers
Subjects:
SAMHD1
DNA damage
DNA repair
TMZ
radiation therapy
malignant glioma
Online Access:https://www.mdpi.com/2072-6694/14/18/4490

Internet

https://www.mdpi.com/2072-6694/14/18/4490

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