Pain and Inflammation as Mediators of Tofacitinib Treatment Effect on Fatigue in Patients with Ankylosing Spondylitis: A Mediation Analysis

Pain and Inflammation as Mediators of Tofacitinib Treatment Effect on Fatigue in Patients with Ankylosing Spondylitis: A Mediation Analysis

Abstract Introduction Tofacitinib is an oral Janus kinase inhibitor for treatment of ankylosing spondylitis (AS). Using mediation modelling, we describe interrelationships between fatigue, pain, morning stiffness, C-reactive protein (CRP) and tofacitinib treatment in patients with AS. Methods Data f...

Full description

Bibliographic Details
Main Authors: Lars Erik Kristensen, Victoria Navarro-Compán, Marina Magrey, Andrew G. Bushmakin, Joseph C. Cappelleri, Arne Yndestad, Oluwaseyi Dina, Peter C. Taylor
Format: Article
Language:English
Published: Adis, Springer Healthcare 2023-06-01
Series:Rheumatology and Therapy
Subjects:
Ankylosing spondylitis
C-reactive protein
Mediation modelling
Morning stiffness
Pain
Tofacitinib
Online Access:https://doi.org/10.1007/s40744-023-00570-0

Internet

https://doi.org/10.1007/s40744-023-00570-0

Similar Items