Megakaryocytes form linear podosomes devoid of digestive properties to remodel medullar matrix

Megakaryocytes form linear podosomes devoid of digestive properties to remodel medullar matrix

Abstract Bone marrow megakaryocytes (MKs) undergo a maturation involving contacts with the microenvironment before extending proplatelets through sinusoids to deliver platelets in the bloodstream. We demonstrated that MKs assemble linear F-actin-enriched podosomes on collagen I fibers. Microscopy an...

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Bibliographic Details
Main Authors: Antoine Oprescu, Déborah Michel, Adrien Antkowiak, Elodie Vega, Julien Viaud, Sara A. Courtneidge, Anita Eckly, Henri de la Salle, Gaëtan Chicanne, Catherine Léon, Bernard Payrastre, Frédérique Gaits-Iacovoni
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-10215-x

Internet

https://doi.org/10.1038/s41598-022-10215-x

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