General Control Nonderepressible 2 and ATF4 Direct Liver Genes during Asparaginase Treatment in Mice
Asparaginase (ASNase) treatment results in the synthesis of some factors such as ATF4. The eIF2-ATF4 pathway is essential for cell survival during amino acid starvation conditions. Activation of the AAR in the liver requires the eIF2 kinase called general control nonderepressible 2 kinase (GCN2). To...
Main Author: | |
---|---|
Format: | Article |
Language: | English |
Published: |
College of Veterinary Medicine
2018-12-01
|
Series: | Al-Qadisiyah Journal of Veterinary Medicine Sciences |
Online Access: | http://www.qu.edu.iq/journalvm/index.php/vm_journal/article/view/516 |