Association between SMAD3 gene polymorphisms and osteoarthritis risk: a systematic review and meta-analysis
Abstract Objective Several studies have been performed to investigate the association between SMAD3 gene polymorphism and osteoarthritis (OA), but the results were inconclusive. This study aims to determine whether SMAD3 polymorphism is associated with risk of OA. Method A comprehensive literature s...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-09-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13018-018-0939-2 |
| _version_ | 1798038565583585280 |
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| author | Jian-qiao Hong Yang-xin Wang Si-hao Li Guang-yao Jiang Bin Hu Yu-te Yang Jia-hong Meng Shi-gui Yan |
| author_facet | Jian-qiao Hong Yang-xin Wang Si-hao Li Guang-yao Jiang Bin Hu Yu-te Yang Jia-hong Meng Shi-gui Yan |
| author_sort | Jian-qiao Hong |
| collection | DOAJ |
| description | Abstract Objective Several studies have been performed to investigate the association between SMAD3 gene polymorphism and osteoarthritis (OA), but the results were inconclusive. This study aims to determine whether SMAD3 polymorphism is associated with risk of OA. Method A comprehensive literature search in PubMed, Embase, and ISI Web of Science for relevant studies was performed. After extracting data from eligible studies, we chose the fixed or random effect model according to the heterogeneity test. Estimation of publication bias and sensitivity analysis were conducted to confirm the stability of this meta-analysis. Results In total, 10 studies from 6 articles with 5093 OA patients and 5699 controls were enrolled in this meta-analysis. The combined results revealed significant association between SMAD3 rs12901499 polymorphism and the risk of OA (allele model: OR 1.21, 95% CI 1.07–1.38). Subgroup analysis revealed that G allele increased the risk of OA in Caucasians, but not in Asians (allele model: Caucasians: OR 1.31, 95% CI 1.18–1.44; Asians: OR 1.24, 95% CI 0.95–1.61). And the pooled results revealed significant association between SMAD3 rs12901499 polymorphism and both knee and hip OA (knee OA: OR 1.18, 95% CI 1.04–1.34; hip OA: OR 1.31, 95% CI 1.18–1.44). Conclusion The current meta-analysis revealed that the G variant of SMAD3 rs12901499 polymorphism increased the risk of OA in Caucasians. Further well-designed studies with larger sample size in different ethnic populations are required to confirm these results. |
| first_indexed | 2024-04-11T21:41:56Z |
| format | Article |
| id | doaj.art-3c60a3f655974a5b9a6d33d2db47082a |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-11T21:41:56Z |
| publishDate | 2018-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-3c60a3f655974a5b9a6d33d2db47082a2022-12-22T04:01:34ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2018-09-011311710.1186/s13018-018-0939-2Association between SMAD3 gene polymorphisms and osteoarthritis risk: a systematic review and meta-analysisJian-qiao Hong0Yang-xin Wang1Si-hao Li2Guang-yao Jiang3Bin Hu4Yu-te Yang5Jia-hong Meng6Shi-gui Yan7Department of Orthopaedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Orthopaedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Orthopaedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Orthopaedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Orthopaedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Orthopaedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Orthopaedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineDepartment of Orthopaedic Surgery, The Second Affiliated Hospital, Zhejiang University School of MedicineAbstract Objective Several studies have been performed to investigate the association between SMAD3 gene polymorphism and osteoarthritis (OA), but the results were inconclusive. This study aims to determine whether SMAD3 polymorphism is associated with risk of OA. Method A comprehensive literature search in PubMed, Embase, and ISI Web of Science for relevant studies was performed. After extracting data from eligible studies, we chose the fixed or random effect model according to the heterogeneity test. Estimation of publication bias and sensitivity analysis were conducted to confirm the stability of this meta-analysis. Results In total, 10 studies from 6 articles with 5093 OA patients and 5699 controls were enrolled in this meta-analysis. The combined results revealed significant association between SMAD3 rs12901499 polymorphism and the risk of OA (allele model: OR 1.21, 95% CI 1.07–1.38). Subgroup analysis revealed that G allele increased the risk of OA in Caucasians, but not in Asians (allele model: Caucasians: OR 1.31, 95% CI 1.18–1.44; Asians: OR 1.24, 95% CI 0.95–1.61). And the pooled results revealed significant association between SMAD3 rs12901499 polymorphism and both knee and hip OA (knee OA: OR 1.18, 95% CI 1.04–1.34; hip OA: OR 1.31, 95% CI 1.18–1.44). Conclusion The current meta-analysis revealed that the G variant of SMAD3 rs12901499 polymorphism increased the risk of OA in Caucasians. Further well-designed studies with larger sample size in different ethnic populations are required to confirm these results.http://link.springer.com/article/10.1186/s13018-018-0939-2SMAD3PolymorphismOsteoarthritisMeta-analysis |
| spellingShingle | Jian-qiao Hong Yang-xin Wang Si-hao Li Guang-yao Jiang Bin Hu Yu-te Yang Jia-hong Meng Shi-gui Yan Association between SMAD3 gene polymorphisms and osteoarthritis risk: a systematic review and meta-analysis Journal of Orthopaedic Surgery and Research SMAD3 Polymorphism Osteoarthritis Meta-analysis |
| title | Association between SMAD3 gene polymorphisms and osteoarthritis risk: a systematic review and meta-analysis |
| title_full | Association between SMAD3 gene polymorphisms and osteoarthritis risk: a systematic review and meta-analysis |
| title_fullStr | Association between SMAD3 gene polymorphisms and osteoarthritis risk: a systematic review and meta-analysis |
| title_full_unstemmed | Association between SMAD3 gene polymorphisms and osteoarthritis risk: a systematic review and meta-analysis |
| title_short | Association between SMAD3 gene polymorphisms and osteoarthritis risk: a systematic review and meta-analysis |
| title_sort | association between smad3 gene polymorphisms and osteoarthritis risk a systematic review and meta analysis |
| topic | SMAD3 Polymorphism Osteoarthritis Meta-analysis |
| url | http://link.springer.com/article/10.1186/s13018-018-0939-2 |
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