Sequence determinants of human-cell entry identified in ACE2-independent bat sarbecoviruses: A combined laboratory and computational network science approach

Sequence determinants of human-cell entry identified in ACE2-independent bat sarbecoviruses: A combined laboratory and computational network science approach

Summary: Background: The sarbecovirus subgenus of betacoronaviruses is widely distributed throughout bats and other mammals globally and includes human pathogens, SARS-CoV and SARS-CoV-2. The most studied sarbecoviruses use the host protein, ACE2, to infect cells. Curiously, the majority of sarbeco...

Full description

Bibliographic Details
Main Authors: Ehdieh Khaledian, Sinem Ulusan, Jeffery Erickson, Stephen Fawcett, Michael C. Letko, Shira L. Broschat
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:EBioMedicine
Subjects:
Coronavirus
Zoonosis
Sequence similarity network
Entry assay
Pseudotype
Mathematical model
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422001748

Internet

http://www.sciencedirect.com/science/article/pii/S2352396422001748

Similar Items