Imatinib Regulates <i>miR-483-3p</i> and Mitochondrial Respiratory Complexes in Gastrointestinal Stromal Tumors

Imatinib Regulates <i>miR-483-3p</i> and Mitochondrial Respiratory Complexes in Gastrointestinal Stromal Tumors

Metabolic adaptation to increased oxidative phosphorylation (OXPHOS) has been found in gastrointestinal stromal tumor (GIST) upon imatinib treatment. However, the underlying mechanism of imatinib-induced OXPHOS is unknown. Discovering molecules that mediate imatinib-induced OXPHOS may lead to the de...

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Bibliographic Details
Main Authors: Wen-Kuan Huang, Hao Shi, Pinar Akçakaya, Katarina Zeljic, Anastasia Gangaev, Stefano Caramuta, Chun-Nan Yeh, Robert Bränström, Catharina Larsson, Weng-Onn Lui
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
gastrointestinal stromal tumor (GIST)
imatinib
microRNA
oxidative phosphorylation
<i>miR-483</i>
succinate dehydrogenase B
Online Access:https://www.mdpi.com/1422-0067/22/19/10600

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https://www.mdpi.com/1422-0067/22/19/10600

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