Investigating and correcting plasma DNA sequencing coverage bias to enhance aneuploidy discovery.

Investigating and correcting plasma DNA sequencing coverage bias to enhance aneuploidy discovery.

Pregnant women carry a mixture of cell-free DNA fragments from self and fetus (non-self) in their circulation. In recent years multiple independent studies have demonstrated the ability to detect fetal trisomies such as trisomy 21, the cause of Down syndrome, by Next-Generation Sequencing of materna...

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Bibliographic Details
Main Authors: Dineika Chandrananda, Natalie P Thorne, Devika Ganesamoorthy, Damien L Bruno, Yuval Benjamini, Terence P Speed, Howard R Slater, Melanie Bahlo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3906086?pdf=render

Internet

http://europepmc.org/articles/PMC3906086?pdf=render

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