Reduction of Streptolysin O (SLO) Pore-Forming Activity Enhances Inflammasome Activation

Reduction of Streptolysin O (SLO) Pore-Forming Activity Enhances Inflammasome Activation

Pore-forming toxins are utilized by bacterial and mammalian cells to exert pathogenic effects and induce cell lysis. In addition to rapid plasma membrane repair, macrophages respond to pore-forming toxins through activation of the NLRP3 inflammasome, leading to IL-1β secretion and pyroptosis. The st...

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Bibliographic Details
Main Authors: Peter A. Keyel, Robyn Roth, Wayne M. Yokoyama, John E. Heuser, Russell D. Salter
Format: Article
Language:English
Published: MDPI AG 2013-06-01
Series:Toxins
Subjects:
NLRP3
inflammasome
Caspase-1
plasma membrane repair
streptolysin O
Online Access:http://www.mdpi.com/2072-6651/5/6/1105

Internet

http://www.mdpi.com/2072-6651/5/6/1105

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