Reduction of Streptolysin O (SLO) Pore-Forming Activity Enhances Inflammasome Activation
Pore-forming toxins are utilized by bacterial and mammalian cells to exert pathogenic effects and induce cell lysis. In addition to rapid plasma membrane repair, macrophages respond to pore-forming toxins through activation of the NLRP3 inflammasome, leading to IL-1β secretion and pyroptosis. The st...
Main Authors: | Peter A. Keyel, Robyn Roth, Wayne M. Yokoyama, John E. Heuser, Russell D. Salter |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2013-06-01
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Series: | Toxins |
Subjects: | |
Online Access: | http://www.mdpi.com/2072-6651/5/6/1105 |
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