Exogenous Ang-(1-7) inhibits autophagy via HIF-1α/THBS1/BECN1 axis to alleviate chronic intermittent hypoxia-enhanced airway remodelling of asthma

Exogenous Ang-(1-7) inhibits autophagy via HIF-1α/THBS1/BECN1 axis to alleviate chronic intermittent hypoxia-enhanced airway remodelling of asthma

Abstract Obstructive sleep apnoea (OSA)-induced chronic intermittent hypoxia (CIH) has been considered a risk factor for severe asthma. Airway remodelling, which could be modulated by autophagy, plays a key role in severe asthma. However, the extent of autophagy’s involvement in CIH-potentiated airw...

Full description

Bibliographic Details
Main Authors: Jian Ping Zhou, Yi Wang, Shi Qi Li, Jia Qi Zhang, Ying Ni Lin, Xian Wen Sun, Li Na Zhou, Liu Zhang, Fang Ying Lu, Yong Jie Ding, Qing Yun Li
Format: Article
Language:English
Published: Nature Publishing Group 2023-10-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01662-0

Internet

https://doi.org/10.1038/s41420-023-01662-0

Similar Items