Congenital Deletion of <i>Nedd4-2</i> in Lung Epithelial Cells Causes Progressive Alveolitis and Pulmonary Fibrosis in Neonatal Mice

Congenital Deletion of <i>Nedd4-2</i> in Lung Epithelial Cells Causes Progressive Alveolitis and Pulmonary Fibrosis in Neonatal Mice

Recent studies found that expression of NEDD4-2 is reduced in lung tissue from patients with idiopathic pulmonary fibrosis (IPF) and that the conditional deletion of <i>Nedd4-2</i> in lung epithelial cells causes IPF-like disease in adult mice via multiple defects, including dysregulatio...

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Bibliographic Details
Main Authors: Dominik H. W. Leitz, Julia Duerr, Surafel Mulugeta, Ayça Seyhan Agircan, Stefan Zimmermann, Hiroshi Kawabe, Alexander H. Dalpke, Michael F. Beers, Marcus A. Mall
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
Nedd4-2
animal model
interstitial lung disease
chILD
ENaC
proSP-C
Online Access:https://www.mdpi.com/1422-0067/22/11/6146

Internet

https://www.mdpi.com/1422-0067/22/11/6146

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