Deletion of the Zinc Transporter Lipoprotein AdcAII Causes Hyperencapsulation of <named-content content-type="genus-species">Streptococcus pneumoniae</named-content> Associated with Distinct Alleles of the Type I Restriction-Modification System

Deletion of the Zinc Transporter Lipoprotein AdcAII Causes Hyperencapsulation of <named-content content-type="genus-species">Streptococcus pneumoniae</named-content> Associated with Distinct Alleles of the Type I Restriction-Modification System

ABSTRACT The capsule is the dominant Streptococcus pneumoniae virulence factor, yet how variation in capsule thickness is regulated is poorly understood. Here, we describe an unexpected relationship between mutation of adcAII, which encodes a zinc uptake lipoprotein, and capsule thickness. Partial d...

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Bibliographic Details
Main Authors: Claire Durmort, Giuseppe Ercoli, Elisa Ramos-Sevillano, Suneeta Chimalapati, Richard D. Haigh, Megan De Ste Croix, Katherine Gould, Jason Hinds, Yann Guerardel, Thierry Vernet, Marco Oggioni, Jeremy S. Brown
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mBio
Subjects:
Streptococcus pneumoniae
capsule expression
virulence
AdcAII
restriction modification
SpnD39III
Online Access:https://journals.asm.org/doi/10.1128/mBio.00445-20

Internet

https://journals.asm.org/doi/10.1128/mBio.00445-20

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