<i>N</i>-Alkyl-2-[4-(trifluoromethyl)benzoyl]hydrazine-1-carboxamides and Their Analogues: Synthesis and Multitarget Biological Activity

<i>N</i>-Alkyl-2-[4-(trifluoromethyl)benzoyl]hydrazine-1-carboxamides and Their Analogues: Synthesis and Multitarget Biological Activity

Based on the isosterism concept, we have designed and synthesized homologous <i>N</i>-alkyl-2-[4-(trifluoromethyl)benzoyl]hydrazine-1-carboxamides (from C<sub>1</sub> to C<sub>18</sub>) as potential antimicrobial agents and enzyme inhibitors. They were obtained fr...

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Bibliographic Details
Main Authors: Martin Krátký, Zsuzsa Baranyai, Šárka Štěpánková, Katarína Svrčková, Markéta Švarcová, Jiřina Stolaříková, Lilla Horváth, Szilvia Bősze, Jarmila Vinšová
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Molecules
Subjects:
antimycobacterial activity
acetylcholinesterase inhibition
butyrylcholinesterase inhibition
cytostatic properties
hydrazides
4-(trifluoromethyl)benzohydrazide
Online Access:https://www.mdpi.com/1420-3049/25/10/2268

Internet

https://www.mdpi.com/1420-3049/25/10/2268

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