Microglial replacement in the aged brain restricts neuroinflammation following intracerebral hemorrhage

Abstract Aged microglia display augmented inflammatory activity after neural injury. Although aging is a risk factor for poor outcome after brain insults, the precise impact of aging-related alterations in microglia on neural injury remains poorly understood. Microglia can be eliminated via pharmaco...

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Bibliographic Details
Main Authors: Xiuping Li, Xiaolin Gao, Wenyan Zhang, Mingming Liu, Zhaoli Han, Minshu Li, Ping Lei, Qiang Liu
Format: Article
Language:English
Published: Nature Publishing Group 2022-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04424-x