Microglial replacement in the aged brain restricts neuroinflammation following intracerebral hemorrhage
Abstract Aged microglia display augmented inflammatory activity after neural injury. Although aging is a risk factor for poor outcome after brain insults, the precise impact of aging-related alterations in microglia on neural injury remains poorly understood. Microglia can be eliminated via pharmaco...
Main Authors: | Xiuping Li, Xiaolin Gao, Wenyan Zhang, Mingming Liu, Zhaoli Han, Minshu Li, Ping Lei, Qiang Liu |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2022-01-01
|
Series: | Cell Death and Disease |
Online Access: | https://doi.org/10.1038/s41419-021-04424-x |
Similar Items
-
Intranasal Delivery of Gene-Edited Microglial Exosomes Improves Neurological Outcomes after Intracerebral Hemorrhage by Regulating Neuroinflammation
by: Mengtian Guo, et al.
Published: (2023-04-01) -
CD22 blockade modulates microglia activity to suppress neuroinflammation following intracerebral hemorrhage
by: Honglei Ren, et al.
Published: (2023-10-01) -
Induced neural stem cells suppressed neuroinflammation by inhibiting the microglial pyroptotic pathway in intracerebral hemorrhage rats
by: Jiaxin Liu, et al.
Published: (2023-07-01) -
Microglial pyroptosis: Therapeutic target in secondary brain injury following intracerebral hemorrhage
by: Lingui Gu, et al.
Published: (2022-09-01) -
Ursolic Acid Alleviates Neuroinflammation after Intracerebral Hemorrhage by Mediating Microglial Pyroptosis via the NF-κB/NLRP3/GSDMD Pathway
by: Pan Lei, et al.
Published: (2023-09-01)