Inhibition of the sarcoplasmic reticulum Ca2+ pump with thapsigargin to estimate the contribution of Na+-Ca2+ exchange to ventricular myocyte relaxation

Inhibition of the sarcoplasmic reticulum Ca2+ pump with thapsigargin to estimate the contribution of Na+-Ca2+ exchange to ventricular myocyte relaxation

Relaxation in the mammalian ventricle is initiated by Ca2+ removal from the cytosol, which is performed by three main transport systems: sarcoplasmic reticulum Ca2+-ATPase (SR-A), Na+-Ca2+ exchanger (NCX) and the so-called slow mechanisms (sarcolemmal Ca2+-ATPase and mitochondrial Ca2+ uptake). To e...

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Bibliographic Details
Main Authors: Bassani R.A., Bassani J.W.M.
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2003-01-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Myocardium
Relaxation
Calcium fluxes
Sodium-calcium exchanger
Sarcoplasmic reticulum calcium ATPase
Caffeine
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001200014

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001200014

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