Identification of Minimal p53 Promoter Region Regulated by MALAT1 in Human Lung Adenocarcinoma Cells

Identification of Minimal p53 Promoter Region Regulated by MALAT1 in Human Lung Adenocarcinoma Cells

The MALAT1 long noncoding RNA is strongly linked to cancer progression. Here we report a MALAT1 function in repressing the promoter of p53 (TP53) tumor suppressor gene. p21 and FAS, well-known p53 targets, were upregulated by MALAT1 knockdown in A549 human lung adenocarcinoma cells. We found that th...

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Bibliographic Details
Main Authors: Keiko Tano, Rena Onoguchi-Mizutani, Fouzia Yeasmin, Fumiaki Uchiumi, Yutaka Suzuki, Tetsushi Yada, Nobuyoshi Akimitsu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Genetics
Subjects:
noncoding RNA
TP53
transcription
genetic
adenocarcinoma
promoter regions
Online Access:http://journal.frontiersin.org/article/10.3389/fgene.2017.00208/full

Internet

http://journal.frontiersin.org/article/10.3389/fgene.2017.00208/full

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