Layer-specific changes of KCC2 and NKCC1 in the mouse dentate gyrus after entorhinal denervation

Layer-specific changes of KCC2 and NKCC1 in the mouse dentate gyrus after entorhinal denervation

The cation-chloride cotransporters KCC2 and NKCC1 regulate the intracellular Cl− concentration and cell volume of neurons and/or glia. The Cl− extruder KCC2 is expressed at higher levels than the Cl− transporter NKCC1 in mature compared to immature neurons, accounting for the developmental shift fro...

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Bibliographic Details
Main Authors: Domenico Del Turco, Mandy H. Paul, Jessica Schlaudraff, Julia Muellerleile, Fran Bozic, Mario Vuksic, Peter Jedlicka, Thomas Deller
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
hippocampus
laser microdissection
RT-qPCR
entorhinal lesion
cation-chloride cotransporters
dedifferentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1118746/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1118746/full

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