Gut microbiota-bile acid crosstalk regulates murine lipid metabolism via the intestinal FXR-FGF19 axis in diet-induced humanized dyslipidemia

Gut microbiota-bile acid crosstalk regulates murine lipid metabolism via the intestinal FXR-FGF19 axis in diet-induced humanized dyslipidemia

Abstract Background Diet-induced dyslipidemia is linked to the gut microbiota, but the causality of microbiota-host interaction affecting lipid metabolism remains controversial. Here, the humanized dyslipidemia mice model was successfully built by using fecal microbiota transplantation from dyslipid...

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Bibliographic Details
Main Authors: Hongtao Xu, Fang Fang, Kaizhang Wu, Jiangping Song, Yaqian Li, Xingyu Lu, Juncheng Liu, Liuyang Zhou, Wenqing Yu, Fei Yu, Jie Gao
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Microbiome
Subjects:
Gut microbiota
Bile acid
Lipid metabolism
FXR
Diet-induced humanized dyslipidemia
Online Access:https://doi.org/10.1186/s40168-023-01709-5

Internet

https://doi.org/10.1186/s40168-023-01709-5

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