Glycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer

Glycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer

Abstract Background Hypoxia-induced glycogen turnover is implicated in cancer proliferation and therapy resistance. Triple-negative breast cancers (TNBCs), characterized by a hypoxic tumor microenvironment, respond poorly to therapy. We studied the expression of glycogen synthase 1 (GYS1), the key r...

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Bibliographic Details
Main Authors: E. C. de Heer, C. E. Zois, E. Bridges, B. van der Vegt, H. Sheldon, W. A. Veldman, M. C. Zwager, T. van der Sluis, S. Haider, T. Morita, O. Baba, C. P. Schröder, S. de Jong, A. L. Harris, M. Jalving
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Glycogen synthase 1
Breast cancer
Glycogen
Mitochondria
Ki67
Online Access:https://doi.org/10.1186/s13046-023-02715-z

Internet

https://doi.org/10.1186/s13046-023-02715-z

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