The acidic tumor microenvironment enhances PD-L1 expression via activation of STAT3 in MDA-MB-231 breast cancer cells

The acidic tumor microenvironment enhances PD-L1 expression via activation of STAT3 in MDA-MB-231 breast cancer cells

Abstract Tumor acidosis, a common phenomenon in solid cancers such as breast cancer, is caused by the abnormal metabolism of cancer cells. The low pH affects cells surrounding the cancer, and tumor acidosis has been shown to inhibit the activity of immune cells. Despite many previous studies, the im...

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Bibliographic Details
Main Authors: Yong-Jin Kwon, Eun-Bi Seo, Ae Jin Jeong, Song-Hee Lee, Kum Hee Noh, Sangsik Lee, Chung-Hyun Cho, Chang-Han Lee, Hyun Mu Shin, Hang-Rae Kim, Hyeong-Gon Moon, Sang-Kyu Ye
Format: Article
Language:English
Published: BMC 2022-08-01
Series:BMC Cancer
Subjects:
Extracellular acidosis
Immune checkpoint
PD-L1
STAT3
MDA-MB-231 cells
Online Access:https://doi.org/10.1186/s12885-022-09956-9

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