Hyaluronic acid restored protein permeability across injured human lung microvascular endothelial cells

Abstract Lung endothelial permeability is a key pathological feature of acute respiratory distress syndrome. Hyaluronic acid (HA), a major component of the glycocalyx layer on the endothelium, is generated by HA synthase (HAS) during inflammation and injury and is critical for repair. We hypothesize...

Full description

Bibliographic Details
Main Authors: Shinji Sugita, Yoshifumi Naito, Li Zhou, Hongli He, Qi Hao, Atsuhiro Sakamoto, Jae W. Lee
Format: Article
Language:English
Published: Wiley 2022-09-01
Series:FASEB BioAdvances
Subjects:
Online Access:https://doi.org/10.1096/fba.2022-00006