15,16-Dihydrotanshinone I inhibits the proliferation of MV4-11 by means of apoptosis via antagonizing FLT3-ITD/STAT5/Mcl-1 pathway

15,16-Dihydrotanshinone I inhibits the proliferation of MV4-11 by means of apoptosis via antagonizing FLT3-ITD/STAT5/Mcl-1 pathway

Till now, the medicines approved for acute myeloid leukemia with internal tandem duplication mutation of FMS-like tyrosine kinase 3 (FLT3-ITD) display not ideal efficacy. This study aimed to evaluate the effects of 15,16-dihydrotanshinone I on FLT3-ITD acute myeloid leukemia cells. The inhibitory e...

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Bibliographic Details
Main Authors: Mansheng Luo, Yanmei Zeng, Xiaoling Deng
Format: Article
Language:English
Published: Bangladesh Pharmacological Society 2023-01-01
Series:Bangladesh Journal of Pharmacology
Subjects:
Acute myeloid leukemia
Apoptosis
15,16-Dihydrotanshinone I
FMS-like tyrosine kinase 3
Internal tandem duplication
Online Access:https://www.banglajol.info/index.php/BJP/article/view/62376

Internet

https://www.banglajol.info/index.php/BJP/article/view/62376

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