Metformin Treatment Attenuates Brain Inflammation and Rescues PACAP/VIP Neuropeptide Alterations in Mice Fed a High-Fat Diet

Metformin Treatment Attenuates Brain Inflammation and Rescues PACAP/VIP Neuropeptide Alterations in Mice Fed a High-Fat Diet

High-fat diet (HFD)-induced comorbid cognitive and behavioural impairments are thought to be the result of persistent low-grade neuroinflammation. Metformin, a first-line medication for the treatment of type-2 diabetes, seems to ameliorate these comorbidities, but the underlying mechanism(s) are not...

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Bibliographic Details
Main Authors: Mawj Mandwie, Jocelyn Karunia, Aram Niaz, Kevin A. Keay, Giuseppe Musumeci, Claire Rennie, Kristine McGrath, Ghaith Al-Badri, Alessandro Castorina
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
high-fat diet
PACAP
VIP
prefrontal cortex
hippocampus
hypothalamus
Online Access:https://www.mdpi.com/1422-0067/22/24/13660

Internet

https://www.mdpi.com/1422-0067/22/24/13660

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