In-Frame Deletion of Dystrophin Exons 8–50 Results in DMD Phenotype

In-Frame Deletion of Dystrophin Exons 8–50 Results in DMD Phenotype

Mutations that prevent the production of proteins in the <i>DMD</i> gene cause Duchenne muscular dystrophy. Most frequently, these are deletions leading to reading-frame shift. The “reading-frame rule” states that deletions that preserve ORF result in a milder Becker muscular dystrophy....

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Bibliographic Details
Main Authors: Tatiana V. Egorova, Ivan I. Galkin, Oleg A. Velyaev, Svetlana G. Vassilieva, Irina M. Savchenko, Vyacheslav A. Loginov, Marina A. Dzhenkova, Diana S. Korshunova, Olga S. Kozlova, Dmitry N. Ivankov, Anna V. Polikarpova
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
Becker muscular dystrophy
mouse model
DMD
BMD
dystrophin
genome editing
Online Access:https://www.mdpi.com/1422-0067/24/11/9117

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https://www.mdpi.com/1422-0067/24/11/9117

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