Structural and Biophysical Insights into SPINK1 Bound to Human Cationic Trypsin

Structural and Biophysical Insights into SPINK1 Bound to Human Cationic Trypsin

(1) The serine protease inhibitor Kazal type 1 (SPINK1) inhibits trypsin activity in zymogen granules of pancreatic acinar cells. Several mutations in the <i>SPINK1</i> gene are associated with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP). The most common variant is S...

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Bibliographic Details
Main Authors: Felix Nagel, Gottfried J. Palm, Norman Geist, Thomas C. R. McDonnell, Anne Susemihl, Britta Girbardt, Julia Mayerle, Markus M. Lerch, Michael Lammers, Mihaela Delcea
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
pancreas
pancreatitis
Kazal inhibitor
serine protease
N34S
protein–protein interaction
Online Access:https://www.mdpi.com/1422-0067/23/7/3468

Internet

https://www.mdpi.com/1422-0067/23/7/3468

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