Simulation of Cl- secretion in epithelial tissues: New methodology estimating activity of electro-neutral Cl- transporter

Simulation of Cl- secretion in epithelial tissues: New methodology estimating activity of electro-neutral Cl- transporter

Transcellular Cl- secretion is, in general, mediated by two steps; 1) the entry step of Cl- into the cytosolic space from the basolateral space across the basolateral membrane by Cl- transporters, such as Na+-K+-2Cl- cotransporter (NKCC1, an isoform of NKCC), and 2) the releasing step of Cl- from th...

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Bibliographic Details
Main Authors: Kouhei eSasamoto, Naomi eNiisato, Akiyuki eTaruno, Yoshinori eMarunaka
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-12-01
Series:Frontiers in Physiology
Subjects:
simulation
mathematical modeling
Cl- channel
Cl- transporter
Epithelial Cl- secretion
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00370/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00370/full

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