EspA acts as a critical mediator of ESX1-dependent virulence in Mycobacterium tuberculosis by affecting bacterial cell wall integrity.

EspA acts as a critical mediator of ESX1-dependent virulence in Mycobacterium tuberculosis by affecting bacterial cell wall integrity.

Mycobacterium tuberculosis (Mtb) requires the ESX1 specialized protein secretion system for virulence, for triggering cytosolic immune surveillance pathways, and for priming an optimal CD8+ T cell response. This suggests that ESX1 might act primarily by destabilizing the phagosomal membrane that sur...

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Bibliographic Details
Main Authors: Alejandra Garces, Krishnamohan Atmakuri, Michael R Chase, Joshua S Woodworth, Bryan Krastins, Alissa C Rothchild, Talia L Ramsdell, Mary F Lopez, Samuel M Behar, David A Sarracino, Sarah M Fortune
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-06-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2891827?pdf=render

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http://europepmc.org/articles/PMC2891827?pdf=render

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