Slow Recovery of Excitability Increases Ventricular Fibrillation Risk as Identified by Emulation

Purpose: Rotor stability and meandering are key mechanisms determining and sustaining cardiac fibrillation, with important implications for anti-arrhythmic drug development. However, little is yet known on how rotor dynamics are modulated by variability in cellular electrophysiology, particularly on...

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Bibliographic Details
Main Authors: Brodie A. Lawson, Kevin Burrage, Pamela Burrage, Christopher C. Drovandi, Alfonso Bueno-Orovio
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Physiology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01114/full