The pentose phosphate pathway in Trypanosoma cruzi: a potential target for the chemotherapy of Chagas disease

The pentose phosphate pathway in Trypanosoma cruzi: a potential target for the chemotherapy of Chagas disease

Trypanosoma cruzi is highly sensitive to oxidative stress caused by reactive oxygen species. Trypanothione, the parasite's major protection against oxidative stress, is kept reduced by trypanothione reductase, using NADPH; the major source of the reduced coenzyme seems to be the pentose phospha...

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Bibliographic Details
Main Authors: Mariana Igoillo-Esteve, Dante Maugeri, Ana L. Stern, Paula Beluardi, Juan J. Cazzulo
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2007-12-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
Trypanosoma cruzi
doença de Chagas
via das pentoses fosfato
estresse oxidativo
produção de NADPH
Chagas disease
pentose phosphate pathway
oxidative stress
NADPH generation
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000400007

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000400007

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