VPS13A knockdown impairs corticostriatal synaptic plasticity and locomotor behavior in a new mouse model of chorea-acanthocytosis

VPS13A knockdown impairs corticostriatal synaptic plasticity and locomotor behavior in a new mouse model of chorea-acanthocytosis

Chorea-acanthocytosis (ChAc) is an inherited neurodegenerative movement disorder caused by VPS13A gene mutations leading to the absence of protein expression. The striatum is the most affected brain region in ChAc patients. However, the study of the VPS13A function in the brain has been poorly addre...

Full description

Bibliographic Details
Main Authors: Esther García-García, Alba Ramón-Lainez, Sara Conde-Berriozabal, Daniel del Toro, Georgia Escaramis, Albert Giralt, Mercè Masana, Jordi Alberch, Manuel J. Rodríguez
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Neurobiology of Disease
Subjects:
Neuronal plasticity
VPS13A disease
Basal ganglia disorders
BDNF
CX3CL1
Long-term depression
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123003078

Internet

http://www.sciencedirect.com/science/article/pii/S0969996123003078

Similar Items