Rapamycin-Induced Feedback Activation of eIF4E-EIF4A Dependent mRNA Translation in Pancreatic Cancer

Rapamycin-Induced Feedback Activation of eIF4E-EIF4A Dependent mRNA Translation in Pancreatic Cancer

Pancreatic cancer cells adapt molecular mechanisms to activate the protein synthesis to support tumor growth. This study reports the mTOR inhibitor rapamycin’s specific and genome-wide effect on mRNA translation. Using ribosome footprinting in pancreatic cancer cells that lack the expression of 4EBP...

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Bibliographic Details
Main Authors: Trang Uyen Nguyen, Harrison Hector, Eric Nels Pederson, Jianan Lin, Zhengqing Ouyang, Hans-Guido Wendel, Kamini Singh
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cancers
Subjects:
mTOR
eIF4E
eIF4A
p70-RSK1
ribosome footprinting
CR-1-31B
Online Access:https://www.mdpi.com/2072-6694/15/5/1444

Internet

https://www.mdpi.com/2072-6694/15/5/1444

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