Azithromycin Differentially Alters TCR-Activated Helper T Cell Subset Phenotype and Effector Function

Azithromycin Differentially Alters TCR-Activated Helper T Cell Subset Phenotype and Effector Function

In addition to their antibiotic activities, azithromycin (AZM) exhibits anti-inflammatory effects in various respiratory diseases. One of the potent anti-inflammatory mechanisms is through inhibition of CD4+ helper T (Th) cell effector function. However, their impact on specific Th subset is obscure...

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Bibliographic Details
Main Authors: Abdul Wahid Ansari, Fatemeh Saheb Sharif-Askari, Manju Nidagodu Jayakumar, Abdul Khader Mohammed, Narjes Saheb Sharif-Askari, Thenmozhi Venkatachalam, Bassam Mahboub, Reinhold E. Schmidt, Rifat Akram Hamoudi, Rabih Halwani, Qutayba Hamid
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
azithromycin
CD4+ helper T cells
anti-inflammatory
CCR4
CXCR3
IFN-γ
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.556579/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.556579/full

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