Practical Synthesis of Phosphinic Dipeptides by Tandem Esterification of Aminophosphinic and Acrylic Acids under Silylating Conditions

Practical Synthesis of Phosphinic Dipeptides by Tandem Esterification of Aminophosphinic and Acrylic Acids under Silylating Conditions

In this report, a synthetic protocol for the preparation of phosphinic dipeptides of type <b>5</b> is presented. These compounds serve as valuable building blocks for the development of highly potent phosphinopeptidic inhibitors of medicinally relevant Zn-metalloproteases and aspartyl pr...

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Bibliographic Details
Main Authors: Paraskevi Kokkala, Kostas Voreakos, Angelos Lelis, Konstantinos Patiniotis, Nikolaos Skoulikas, Laurent Devel, Angeliki Ziotopoulou, Eleni Kaloumenou, Dimitris Georgiadis
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Molecules
Subjects:
phosphinic
pseudopeptides
<i>P</i>-Michael
silylation
hexamethyldisilazane
inhibitors
Online Access:https://www.mdpi.com/1420-3049/27/4/1242

Internet

https://www.mdpi.com/1420-3049/27/4/1242

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